Wednesday, June 27, 2012

Steroids Won't Help If You're a Loser

The more we study physiology and behavior across groups of animals, the more we find we have in common in the types of behaviors we express and the biological machinery of how our bodies influence what behaviors are expressed and when. But similarity does not mean the same. Sometimes seemingly small physiological differences can have big behavioral consequences.

A snuggly California mouse pair.
Photo from the Marler lab.
A lone wire-walking white-footed mouse.
Photo by the National Park Service.
Take the California mouse and the white-footed mouse, for example. Both are small grayish to brownish species of North American deer mice (the Peromyscus genus). But behaviorally, these species are quite different. One noticeable difference in their behavior is that California mice are very territorial and dominant towards intruders, whereas white-footed mice are more welcoming of other mice (or at least more ambivalent to their presence). These species also differ in how they respond to dominance challenges: California mice that win a challenge (by getting their opponent to show submissive behavior) are more likely to win future challenges (this phenomenon is called the Winner Effect). However, white-footed mice have the same probability of winning or losing a challenge regardless of whether they won or lost the previous one. Interestingly, the experience of winning causes the levels of testosterone (a steroid hormone) to surge in California mice, but not in white-footed mice. Could this difference in testosterone explain this difference in behavior between these two species?

Cathy Marler and her colleagues at the University of Wisconsin at Madison recently explored this question. They compared four groups of male mice: (1) California mice that won three challenges and had a saline injection after each win, (2) white-footed mice that won three challenges and had a testosterone injection after each win, (3) white-footed mice that won three challenges and had a saline (without hormone) injection after each win, and (4) white-footed mice that were handled by researchers three times (and had no dominance challenges) and had a testosterone injection after each time they were handled. Then they placed each mouse with a new challenger and measured what percentage of males in each group were dominant versus subordinate.

Most California mouse males that have been previously dominant and had
no hormone treatment win a future dominance challenge (black bar).
White-footed mice (grey bars) are only likely to win their next dominance challenge
if they had previously won AND had additional testosterone (W+T), but not if they
won without added testosterone (W+S) or had testosterone without wins (H+T).
Figure from Fuxjager et al., 2011, Proc. R. Soc. B.
Marler and her colleagues found that similar to the natural state, white-footed mice that won three times and were not injected with testosterone were less likely to win a later challenge than California mice that also won three times and were not injected with testosterone. But, white-footed mice that won three times and were injected with testosterone won their next challenge as often as the California mice did! Presumably, the California mice had their own natural surge of testosterone whenever they had a winning experience and the testosterone injections given to the white-footed mice after their wins mimicked this effect and increased their odds of winning later.

However, testosterone injections alone were not enough to increase the chances of winning: the white-footed mice that had testosterone injections without winning challenges were just as likely to lose their next challenge as those that had saline injections and won previous challenges. It’s the combination of winning experience paired with a surge of testosterone that is the winning formula. You can think of it this way: When (fictional) scientists gave frail Steve Rogers "Super Soldier Serum" to turn him into Captain America, it only worked because Steve Rogers was already a winner at heart. Had they given the serum to someone less remarkable, Michael Cera, for example, they just would have ended up with this:
Michael Cera's attempt to be Captain America. Photo by Gage Skidmore.
So what does this all mean? For one thing, it appears that white-footed mice have all of the necessary brain-wiring to show a Winner Effect in the same way that California mice do, but they don’t produce the testosterone surge to activate it. This opens up a bunch of new questions, like: Why don’t white-footed mice have a testosterone surge after winning? Is there some aspect of their lifestyle that would make such a testosterone surge costly? How does the body know to release testosterone in response to a social experience anyway? Other than testosterone, what makes a winner a winner?

In the end, the experience of winning is critical to the Winner Effect: Testosterone alone won’t help you win your next challenge. So don’t think steroids are gonna help you if you suck at your sport of choice. You have to already be a winner for extra testosterone to help you win… and at that point, who needs it?

Want to know more? Check these out:

1. Fuxjager MJ, Montgomery JL, & Marler CA (2011). Species differences in the winner effect disappear in response to post-victory testosterone manipulations. Proceedings. Biological sciences / The Royal Society, 278 (1724), 3497-503 PMID: 21490015

2. Oyegbile TO, & Marler CA (2005). Winning fights elevates testosterone levels in California mice and enhances future ability to win fights. Hormones and behavior, 48 (3), 259-67 PMID: 15979073

15 comments:

  1. > You have to already be a winner for extra testosterone to help you win… and at that point, who needs it?

    Obviously, the white-footed mice need it because they "are only likely to win their next dominance challenge if they had previously won AND had additional testosterone (W+T), but not if they won without added testosterone (W+S)". It's an interesting article but the conclusion is off.

    ReplyDelete
  2. I agree with most of the blog, you make very good points about the mice. It sounds like the researchers are using the principle of classical conditioning because they are taking the neutral stimulus and injecting the mice with the testosterone to result in a faster mouse. It may not be the perfect idea here but it is very similar. I think that the awesome and most interesting part about this is that results happen in just a couple of minutes, anyways, great article!

    ReplyDelete
  3. Why the choice of "three challenges"? Does this mean that white-footed mice are equal to Cali mice up to three wins but falter afterwards, unless injected with testosterone?

    ReplyDelete
    Replies
    1. No, white-footed mice don't seem to show the winner effect after any number of wins unless they are given extra testosterone. This is very different from California mice. I think the researchers have settled on three challenges because it is enough to get a measurable effect in California mice... and to do more is probably not worth the extra time, money and mouse-stress.

      Delete
  4. It is important for an athlete to realize the capabilities of his body and take dosage of steroids accordingly else steroids can prove to be lethal.

    Steroids Canada

    ReplyDelete
  5. This comment has been removed by the author.

    ReplyDelete
  6. You pointed out how loser they must if they don't know what's the real reason of steroids or what is steroids, then it would be a BIG yes for me it's because like anabolic steroids is made for a big reason for all weight lifters to gain a perfect shape to their muscles.

    ReplyDelete
  7. Wow, excellent post. I'd like to draft like this too - taking time and extremely hard work to make a great article. This post has inspired me to write some posts that I am going to write soon on Steroids for Sale Online in USA.

    ReplyDelete
  8. I liked your article and found it informative. And especially the title you mentioned for your blog. This post has inspired me to write some article that I am going to write soon on the topic Steroids UK Online.

    ReplyDelete
    Replies
    1. Contact: +1 (434) 207-2235

      Our goal is to offer our customers economical and convenient access to medicines with a personal and discreet service.
      We offer Quest Chemicals Online, US Online Chemist, Pharmacy website, best chemicals online, online pills, best steriods online available

      Email: quest4chem@gmail.com
      Contact: +1 (434) 207-2235

      Delete
  9. Text/Call: +14049266094

    anabolic Steroid Pharma Shop, pharmaceutical, qualified lawyer, Steroid Pharma Shop. Good Stuff Available I’m allowed over 50 pounds in my possession. I am looking to supply a min of 1 oz of the following pills to anyone who wants grade. We do discreet ######## and no signatures during delivery. The parcel has no label indicating it is carrying the what. We do give high discounts for orders above 2 to 3 pound.


    For all interested, do email us back with your order. Below is some of our available strains Good for Pain, cancer, insomnia..

    #anabolic Steroid Pharma Shop::::::::::::: Grade: AA

    #pharmaceutical:::::::::::::::Grade: AA+

    #qualified lawyer::::Grade: A

    #Steroid Pharma Shop :::::::Grade: AA


    And many more..


    Deliveries 24/7 everywhere!!!! very clean smelling, awesome taste and VERY potent hash oil. purged for hours so no impurities left. used stainless steel tubes.


    Phone: +14049266094

    E-mail: info@steriodspharmashop.com

    Website: https://steroidspharmashop.com/

    ReplyDelete
  10. ext/Call: + 1 424 835 1429

    dextripam, asimax, ansomon, candy tablet press machine, dextripam diazepam, actavis cough syrup, dianoxyl 50. Good stuffs Available I’m allowed maximum in my possession. I am looking to supply a min of 1 oz of the following steriods to anyone who wants . We do discreet ######## and no signatures during delivery. The parcel has no label indicating it is carrying the what. We do give high discounts for orders above 2 to 3 pound



    For all interested, do email us back with your order. Below is some of our available strains Good for Pain, cancer, insomnia..

    #dextripam online:::::::::::: Grade: AA

    #asimax online:::::::::::::::Grade: AA+

    # ansomon online::::Grade: A

    #candy tablet press machine :::::::Grade: AA

    #actavis cough syrup::::::::::::Grade: AA

    #dianoxyl 50::::::Grade: A

    And many more..


    Deliveries 24/7 everywhere!!!! very clean smelling, awesome taste and VERY potent stuff. purged for hours so no impurities left.


    Phone: + 1 424 835 1429

    E-mail: info@megacurepharmacy.com

    Website: https://megacurepharmacy.com/

    ReplyDelete
  11. Contact: +14248351429

    Visit the online store for the best medicines. trythe medicines with or without prescrption
    Buy online medicines, buy steriods, online pills, online pharmacy availble, online pharmacy, Best Online Pharmaceuticals

    Store, Buy Medicine Online. Mega Cure Pharmacy Pain Killers, Pills, Research Chemicals and Powders, Steroid, Weight Loss

    and Women’s Health.


    Contact: +14248351429
    Email: info@megacurepharmacy.com
    Website: https://megacurepharmacy.com/

    ReplyDelete
  12. This comment has been removed by the author.

    ReplyDelete
  13. Testosterone Propionate is a fast-acting testosterone ester commonly used by bodybuilders and athletes to support muscle growth, strength, and endurance. When looking for it for sale, it’s crucial to buy from trusted sources to ensure product purity and authenticity, as well as to avoid counterfeit products. Potential users should consult with a healthcare professional to understand the correct dosage and possible side effects. It’s also important to be aware of any legal restrictions in your area related to the purchase and use of Testosterone Propionate.
    testosterone propionate for sale

    ReplyDelete